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Published on: September 5, 2019
Rat tissue reaction to MTA FILLAPEX®
João Eduardo Gomes-Filho1, Simone Watanabe, Carolina Simonetti Lodi
1Department of Endodontics, Araçatuba School of Dentistry, University of Estadual Paulista, R. José Bonifácio 1193, Araçatuba, São Paulo, Brazil. joao@foa.unesp.br
Summary
Mineral trioxide aggregate (MTA) FILLAPEX® demonstrated biocompatibility and stimulated mineralization in rat subcutaneous tissue. MTA FILLAPEX® and Angelus MTA® showed mild tissue reactions after 15 days, indicating good biocompatibility.
Area of Science:
- Biomaterials Science
- Dental Materials Research
- Tissue Engineering
Background:
- Biocompatibility assessment is crucial for dental materials.
- Mineral trioxide aggregate (MTA) and Sealapex® are commonly used in endodontics.
- Understanding tissue response to new MTA formulations is essential.
Purpose of the Study:
- To evaluate subcutaneous tissue reaction to MTA FILLAPEX®.
- To compare MTA FILLAPEX® with Sealapex® and Angelus MTA®.
- To assess the biocompatibility and mineralization potential of MTA FILLAPEX®.
Main Methods:
- Polyethylene tubes filled with test materials were implanted in Wistar rats.
- Subcutaneous tissue reactions were evaluated at 7, 15, 30, 60, and 90 days.
- Histological analysis included hematoxylin and eosin, Von Kossa staining, and polarized light microscopy.
Main Results:
- All tested materials initially caused moderate tissue reactions, which decreased over time.
- MTA FILLAPEX® and Angelus MTA® exhibited mild reactions from day 15 onwards.
- Mineralization and birefringent granulation tissue were observed with all materials.
Conclusions:
- MTA FILLAPEX® is biocompatible and promotes mineralization.
- MTA FILLAPEX® shows a favorable tissue response compared to Sealapex® and similar to Angelus MTA®.
- The study supports the use of MTA FILLAPEX® in dental applications requiring biocompatibility and mineralization.
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