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Monozygotic twins discordant for partial trisomy 1.
W J Watson1, V L Katz, S G Albright
1Department of Obstetrics and Gynecology, Biological Sciences Research Center, University of North Carolina, Chapel Hill.
Obstetrics and Gynecology
|November 1, 1990
Summary
Monozygotic twins, though identical at conception, can develop genetic differences. A case study highlights how genomic rearrangement after twinning leads to discordant anomalies and partial trisomy 1 mosaicism.
Area of Science:
- Genetics
- Developmental Biology
- Reproductive Medicine
Background:
- Monozygotic twins are generally considered genetically identical.
- Discordance in monozygotic twins can arise from post-zygotic genetic events.
- Partial trisomy 1 is a rare chromosomal abnormality associated with specific developmental defects.