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[Receptors for oreksins: structure, localisation and activation mechanisms]

T V Abramova, S V Perekrest, K Z Shainidze

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |December 15, 2011
    PubMed

    Insights

    This review details orexin receptor structure, signaling, and functions. It explores how orexin receptors in the brain and body regulate physiology and the impact of antagonists.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Pharmacology

    Context:

    • Orexin receptors (OX1R, OX2R) are G-protein coupled receptors crucial for physiological regulation.
    • Orexins act centrally and peripherally, influencing diverse biological functions.
    • Understanding orexin receptor mechanisms is key to developing targeted therapeutics.

    Purpose:

    • To review the morpho-functional characteristics of orexin receptors.
    • To present data on orexin receptor structure, signal transduction, and biological effects.
    • To analyze the effects of orexin receptor antagonists.

    Summary:

    • Orexin receptors (OX1R, OX2R) exhibit diverse G-protein associations, mediating distinct signal transduction pathways and biological effects.
    • Their localization in the central nervous system and peripheral organs highlights their role in regulating physiological functions.
    • Analysis of orexin receptor antagonists provides insights into therapeutic potential.

    Impact:

    • Provides a comprehensive overview of orexin receptor biology for researchers.
    • Highlights the potential for therapeutic interventions targeting the orexin system.
    • Facilitates understanding of orexin's role in homeostasis and disease.

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