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An uneventful pregnancy and delivery, in a case with chronic myeloid leukemia on imatinib

Jovita Martin1, Anita Ramesh, Lalitha Devadasan

  • 1Department of Oncology, Sri Ramachandra Medical College, Sri Ramachandra Medical College and Hospital, Porur, India.

Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology
|December 17, 2011
PubMed

The concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 24-year-old woman in the first trimester of her pregnancy with chronic myelogenous leukemia (CML) in the chronic phase, who was on treatment with imatinib, which was stopped by 10(th) week of pregnancy. Until, she completed full term of pregnancy she was on hydroxyurea. The use of imatinib did not have adverse effects on the fetus. The patient had a normal vaginal delivery and gave birth to a healthy 2500 g girl at 37 weeks of gestation. We conclude that imatinib in the first trimester of pregnant lady with CML, though has particular concern regarding the potential teratogenic and other adverse effects, has shown evidences of safe conception, pregnancy and delivery in ladies with CML.

Keywords:
CML in pregnancyimatinib in pregnancysafety of imatinib in pregnancy

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