Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Probiotics

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...

Microbiota of the Urogenital Tract

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Predictive Value of Prostate-Specific Antigen Density: A Retrospective Analysis of Likert 3 Multiparametric MRI of the Prostate.

Cureus·2023

Same author

Peyronie's Disease: A Brief Overview.

Cureus·2023

Same author

Robotic assisted partial nephrectomy reduces warm ischemia time and improves renal function acutely compared to the traditional laparoscopic approach; A single surgeon twin centre study.

Journal of robotic surgery·2023

Same author

Primary Ewing sarcoma of the kidney presenting as haematuria in a pregnant woman - A case report highlighting the diagnostic and therapeutic dilemmas of the condition in pregnancy.

Urology case reports·2023

Same author

Benefits of Robotic Assisted vs. Traditional Laparoscopic Partial Nephrectomy: A Single Surgeon Comparative Study.

Journal of clinical medicine·2022

Same author

Research Participation Influences Willingness to Reduce Zoonotic Exposure in Uganda.

EcoHealth·2022

Search research articles

Related Experiment Video

Updated: May 26, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Probiotics, dendritic cells and bladder cancer.

Oladapo Feyisetan¹, Christopher Tracey, Giles O Hellawell

¹Department of Urology, University College London Hospitals NHS Trust, London, UK.

BJU International

|December 20, 2011

Summary

Probiotics may suppress superficial bladder cancer by activating natural killer (NK) cells, potentially through dendritic cells (DCs). This research sheds light on how probiotics influence the immune system to combat bladder cancer.

More Related Videos

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Related Experiment Videos

Last Updated: May 26, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Area of Science:

Immunology
Oncology
Microbiology

Background:

The immune-suppressive effect of probiotics on superficial bladder cancer is recognized, but the underlying mechanisms remain unclear.
Natural killer (NK) cells are identified as key anti-tumor effector cells, with their activity correlating to anti-cancer effects in preclinical models.
Dendritic cells (DCs) are known to recruit and mobilize NK cells, suggesting they may be the crucial interface for probiotic action.

Purpose of the Study:

To investigate the mechanism by which probiotics exert their anti-tumor effects on superficial bladder cancer.
To explore the role of dendritic cells (DCs) and natural killer (NK) cells in the anti-cancer activity of probiotics.
To understand how probiotic intervention might modulate immune responses relevant to bladder cancer treatment.

Main Methods:

Observed the suppressor effect of probiotics on superficial bladder cancer.
Correlated NK cell activity with the anti-tumor effect in animal models.
Investigated the role of DCs in NK cell recruitment and mobilization.
Examined the impact of NK cell purification on NK cell activity.

Main Results:

Evidence strongly suggests that NK cells are the effector cells responsible for the anti-tumor effects of probiotics.
NK cell activity was found to correlate with the observed anti-tumor effects in mice.
Purification of NK cells led to a decrease in their activity, supporting their role in the anti-cancer mechanism.

Conclusions:

Dendritic cells (DCs) are likely the cellular interface through which probiotics exert their influence on NK cells.
Understanding the probiotic-DC-NK cell axis could offer novel immunotherapeutic strategies for superficial bladder cancer.
Probiotics may represent a complementary approach to existing treatments like intravesical bacille Calmette-Guérin (BCG) by modulating the immune response.