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Skin cancers and their etiologies

Ashfaq A Marghoob1

  • 1Memorial Sloan-Kettering Skin Cancer Center, Hauppauge, New York, USA. marghooa@MSKCC.ORG

Seminars in Cutaneous Medicine and Surgery
|December 20, 2011
PubMed

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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