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Updated: May 26, 2026

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Published on: October 27, 2014
Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities
Yujie Dang1, Yingying Qin, Rong Tang
1Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, People's Republic of China.
Objective:
To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs).
Design:
Phenotypic and mutational study.
Setting:
University hospital.
Patient(S):
A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals.
Intervention(S):
Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants.
Main Outcome Measure(S):
Not applicable.
Result(S):
The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs).
Conclusion(S):
The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.
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