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Lower extremity venography with iohexol: results and complications
A W Lensing1, P Prandoni, H R Büller
1Center for Thrombosis, Hemostasis and Atherosclerosis Research, Academic Medical Center, Amsterdam Zuidoost, The Netherlands.
Radiology
|November 1, 1990
Summary
Iohexol, a nonionic contrast agent, was evaluated for side effects during venography for deep-vein thrombosis (DVT). Results show iohexol has a low frequency of adverse reactions compared to older agents.
Area of Science:
- Radiology
- Pharmacology
Background:
- Venography is crucial for diagnosing deep-vein thrombosis (DVT).
- Contrast agents used in venography can cause adverse reactions.
- Iohexol is a nonionic contrast agent with a potentially improved safety profile.
Purpose of the Study:
- To assess the frequency and types of side effects associated with iohexol during venography for suspected DVT.
- To compare the adverse reaction profile of iohexol with conventional high-osmolar ionic contrast agents.
Main Methods:
- A study of 463 consecutive patients undergoing venography for suspected DVT.
- Inclusion of a comparison group receiving iohexol or a high-osmolar ionic compound.
- Monitoring and documentation of all minor and serious adverse reactions.
Main Results:
- Minor side effects (pain, nausea, dizziness, etc.) occurred in 17.9% of patients.
- Serious adverse reactions, such as bronchospasm, were rare (0.4%).
- Postvenographic thrombosis occurred in 2% of patients with prior normal venograms.
Conclusions:
- Iohexol is associated with a significantly lower frequency of side effects compared to high-osmolar contrast agents.
- Minor side effects are common (approx. 18%), but serious reactions are rare.
- Iohexol appears to be a safe contrast agent for venography in patients with suspected DVT.