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Obstructive sleep apnea and P300 evoked auditory potential
Carlos Henrique Martins1, Ney de Castro Júnior, Orozimbo Alves Costa Filho
1Depto de Fonoaudiologia, Fac de Odontologia, UNESP.
Brazilian Journal of Otorhinolaryngology
|December 21, 2011
Summary
Obstructive sleep apnea syndrome (OSAS) is linked to cognitive issues. Auditory P300 amplitude reduction in OSAS patients suggests impaired auditory memory and cognitive dysfunction.
Area of Science:
- Neuroscience
- Sleep Medicine
- Cognitive Psychology
Background:
- Obstructive sleep apnea syndrome (OSAS) negatively impacts cognitive functions like attention and memory.
- Auditory P300 event-related potentials offer a potential biomarker for cognitive dysfunction.
Purpose of the Study:
- To compare polysomnography data and auditory P300 parameters in primary snorers and OSAS patients.
- To investigate the relationship between OSAS severity and cognitive markers.
Main Methods:
- A prospective study involving 12 primary snorers and 54 OSAS patients.
- Polysomnography was used to determine the apnea-hypopnea index (AHI).
- Auditory P300 variables were analyzed and compared using statistical tests including t-Student, Fisher's Exact Test, and logistic regression.
Main Results:
- The OSAS group exhibited a lower prevalence of P300 abnormalities (p=0.027).
- A significantly lower P300 amplitude was observed in OSAS patients (p=0.003).
- P300 latency remained similar between groups (p=0.89), and age did not affect P300 prevalence (p=0.232).
Conclusions:
- Reduced P300 amplitude in OSAS patients indicates cognitive dysfunction.
- This dysfunction is likely associated with diminished auditory memory capacity in OSAS.
- Auditory P300 analysis can aid in identifying cognitive impairments in OSAS.
