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Total synthesis of halichondrin C

Akihiko Yamamoto1, Atsushi Ueda, Paul Brémond

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|December 23, 2011
PubMed
Summary

The first total synthesis of halichondrin C was achieved using novel methods for constructing its complex polycycle. Acid stability studies revealed the macrolactone

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