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Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
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Published on: February 12, 2011

Simple method for MR gradient system characterization and k-space trajectory estimation.

Nii Okai Addy1, Holden H Wu, Dwight G Nishimura

  • 1Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA. noaddy@mrsrl.stanford.edu

Magnetic Resonance in Medicine
|December 23, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a new method to correct artifacts in fast MRI scans caused by gradient system imperfections. The technique accurately predicts magnetic resonance imaging (MRI) k-space trajectories, reducing image distortions for various imaging sequences.

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging (MRI)
  • Signal Processing

Background:

  • Fast imaging techniques in MRI are crucial for reducing scan times but are susceptible to artifacts.
  • Gradient system imperfections lead to deviations between intended and actual k-space trajectories, causing image artifacts.
  • Existing artifact reduction methods are often trajectory- and orientation-specific.

Purpose of the Study:

  • To develop a universal method for characterizing gradient system behavior.
  • To predict actual k-space trajectories for arbitrary scan orientations.
  • To reduce image artifacts in fast MRI acquisitions.

Main Methods:

  • A single linear time-invariant (LTI) characterization of the gradient system was employed.
  • The method utilizes convolution to predict k-space trajectories based on gradient system properties.
  • Efficient characterization is achieved by comparing Fourier transforms of input and measured waveforms of a test gradient.
  • The technique was validated across spiral, interleaved echo-planar, and 3D cones imaging trajectories.

Main Results:

  • The LTI characterization effectively predicted k-space trajectories for tested imaging sequences.
  • The proposed method demonstrated significant reduction in reconstructed image artifacts.
  • The approach proved effective for various k-space trajectories and scan orientations.

Conclusions:

  • A novel, efficient method for characterizing gradient system performance in MRI was presented.
  • This technique enables accurate prediction of k-space trajectories, mitigating artifacts in fast imaging.
  • The findings offer a generalizable solution for improving image quality in diverse MRI applications.