Malignant fibrous histiocytoma-case report.

Area of Science:

• Oral pathology
• Oncology
• Dermatopathology

Background:

• Fibrous histiocytoma (FH) is a tumor of fibroblastic and histiocytic cells, typically found on the skin.
• Deep tissue FH diagnosis can be challenging, often requiring histopathological confirmation post-excision.
• Distinguishing FH from aggressive fibrohistiocytic neoplasms is crucial for appropriate management.

Observation:

• A unique case of malignant fibrous histiocytoma (MFH) occurred in the left buccal mucosa.
• This MFH developed near the surgical margin of a prior benign fibrous histiocytoma excision from the mandible.
• The patient was a 31-year-old female.

Findings:

• Clinical and histopathological data did not establish a definitive link between the initial benign FH and the subsequent malignant counterpart.
• The proximity of the MFH to the prior excision site raises questions about potential recurrence or transformation.

Implications:

• This case highlights the diagnostic difficulties of deep-seated fibrous histiocytomas.
• It underscores the importance of thorough histopathological evaluation, especially in cases with a history of prior fibrohistiocytic lesions.
• Further investigation may be needed to understand potential associations between benign and malignant fibrous histiocytomas in specific locations.