Epidemiological Analysis of Cleft Lip and/or Palate by Cleft Pattern.

Area of Science:

• Craniofacial anomalies
• Medical genetics
• Clinical research

Background:

• Cleft lip and/or cleft palate (CL/P) are common congenital anomalies.
• Understanding gender-specific patterns in CL/P is crucial for diagnosis and treatment.
• Previous studies have suggested gender-based variations in CL/P, but detailed analysis is needed.

Purpose of the Study:

• To investigate gender differences in the patterns of cleft lip and/or cleft palate (CL/P) in a Japanese cohort.
• To utilize clinical statistical analysis for detailed classification of CL/P based on gender.
• To explore the relationship between gender and the severity and type of CL/P.

Main Methods:

• A retrospective clinical statistical study was conducted on 782 Japanese patients with CL/P.
• Patients were examined at the Cleft Lip and Palate Center, Aichi-Gakuin University Hospital.
• Cleft pattern modeling and chi-squared tests were employed to analyze gender and cleft type relationships.

Main Results:

• A significant association was found between gender and cleft pattern.
• Males were more prevalent in milder forms of cleft lip, cleft lip and palate, and cleft palate.
• Females showed a higher prevalence as the severity of the cleft increased.

Conclusions:

• Cleft pattern modeling offers a refined method for classifying CL/P.
• Gender is a significant factor influencing CL/P patterns and severity.
• This detailed classification can enhance the understanding of CL/P pathology and inform clinical management.