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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
[A case of primary pleural angiosarcoma metastasing to the bladder]
Satoshi Otsubo1, Shingo Tanaka, Yoriyuki Kamiryo
1Department of Urology, Nippon Steel Yawata Memorial Hospital.
Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|December 24, 2011
Summary
A rare case of metastatic pleural angiosarcoma to the urinary bladder is presented. This aggressive cancer, originating in the pleura, presented with bladder symptoms and was difficult to diagnose, highlighting the need for awareness.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- A 79-year-old male with a history of pulmonary tuberculosis treated with plombage presented with benign prostatic hyperplasia (BPH).
- The patient developed macrohematuria, fatigue, and anemia, with initial investigations showing no clear cause.
Observation:
- Transurethral resection of the bladder tumor (TURBT) revealed bleeding mucosal sites but lacked definitive diagnostic features.
- Initial CT scans and cytology were inconclusive, though histology suggested a malignant vasoformative tumor.
Findings:
- Autopsy confirmed a primary pleural angiosarcoma with extensive metastases to the thoracic wall, adrenals, bone, stomach, and urinary bladder.
- Microscopic analysis showed atypical cells forming vascular structures, positive for CD31 and vimentin, confirming angiosarcoma.
Implications:
- Metastatic angiosarcoma to the urinary bladder is exceedingly rare and poses significant diagnostic challenges.
- Clinical awareness and consideration of this rare entity are crucial for timely diagnosis and management.
