Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING.

bioRxiv : the preprint server for biology·2026

Same author

3D Chromosome Remodeling in B-cell Development and Acute Lymphoblastic Leukemia.

Blood cancer discovery·2026

Same author

Diffusive and Enzymatic Modulation of the Dynamic Size Distribution of DNA Droplets.

Physical review letters·2026

Same author

Diverse, distinct, and densely packed DNA nanostar droplets.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

A developmentally regulated long-range enhancer-promoter contact mediates human neural development.

bioRxiv : the preprint server for biology·2026

Same author

Competition between glycine and GABA<sub>A</sub> receptors for gephyrin controls their equilibrium populations at inhibitory synapses.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same journal

High-Throughput Microbial Assay for Amino Acid Measurement in Ground Maize Seed Samples Utilizing Auxotrophic <i>E. coli</i>.

Cold Spring Harbor protocols·2025

Same journal

Grain Quality in Maize.

Cold Spring Harbor protocols·2025

Same journal

High-Throughput Assay for Measuring Phytate and Available Phosphorus in Ground Maize Seed Samples.

Cold Spring Harbor protocols·2025

Same journal

Functional Genomic Analysis of Transposon Insertion Mutant Maize Plants from the UniformMu National Public Resource.

Cold Spring Harbor protocols·2025

Same journal

The UniformMu National Public Resource: Transposon<i>-</i>Induced Mutant Seeds for Functional Genomics Studies in Maize.

Cold Spring Harbor protocols·2025

Same journal

Insights from the Study of B<i>-</i>Cell Epitopes of a Microbial Pathogen by Phage Display.

Cold Spring Harbor protocols·2025

See all related articles

Search research articles

Related Experiment Video

Updated: May 26, 2026

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

Single-molecule studies using magnetic traps.

Timothée Lionnet, Jean-François Allemand, Andrey Revyakin

Cold Spring Harbor Protocols

|December 24, 2011

Summary

This summary is machine-generated.

The magnetic trap technique allows precise stretching and twisting of single DNA molecules. This method offers absolute force measurement for studying DNA elasticity and protein interactions.

More Related Videos

High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements

High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements

Published on: May 12, 2023

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

Related Experiment Videos

Last Updated: May 26, 2026

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements

High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements

Published on: May 12, 2023

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

Area of Science:

Biophysics
Molecular Biology
Nanotechnology

Background:

Single-molecule manipulation techniques are crucial for understanding biopolymer behavior.
The magnetic trap offers a novel approach to probe DNA mechanics and interactions.

Purpose of the Study:

To describe the principles and applications of the magnetic trap technique.
To demonstrate its utility in measuring DNA elastic properties and studying DNA-protein interactions.

Main Methods:

Utilizing a magnetic trap to bind and manipulate single DNA molecules.
Applying controlled forces (10^-3 to >100 pN) to stretch and twist DNA.
Employing absolute force measurement without sensor calibration.

Main Results:

The magnetic trap enables precise control over DNA stretching and twisting.
Absolute force measurements provide reliable data for biophysical studies.
The technique facilitates the investigation of DNA elasticity and protein binding dynamics.

Conclusions:

The magnetic trap is a powerful tool for single-molecule biophysics.
It provides new insights into the mechanical properties of DNA and its interactions with proteins.