Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation in pulmonary tuberculosis.

K S Sai Baba1, K D Moudgil, R C Jain

  • 1Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar.

Tubercle
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pristimerin inhibits the progression of antibody-induced autoimmune arthritis.

Scandinavian journal of rheumatology·2024
Same author

Lead as a Risk Factor for Osteoporosis in Post-menopausal Women.

Indian journal of clinical biochemistry : IJCB·2017
Same author

Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review.

Indian journal of clinical biochemistry : IJCB·2016
Same author

Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease.

Indian journal of clinical biochemistry : IJCB·2016
Same author

Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage.

International journal of immunopathology and pharmacology·2015
Same author

Latent iron deficiency at birth influences auditory neural maturation in late preterm and term infants.

The American journal of clinical nutrition·2015
Same journal

Trimethylene-glycol-phenol mixture for rapid staining of the tubercle bacillus.

Tubercle·2010
Same journal

Mass x-ray of pregnant women.

Tubercle·2010
Same journal

Extrapleural pneumothorax.

Tubercle·2010
Same journal

Tuberculosis of skeleton and lung combined; prognosis and treatment.

Tubercle·2010
Same journal

Artificial pneumothorax in patients with high blood sedimentation rate.

Tubercle·2010
Same journal

Tuberculosis in Sweden and the fight against it in recent years.

Tubercle·2010
See all related articles

Complement levels (CH50, C3, C3d) and immune complexes (CICs) are elevated in untreated tuberculosis patients, correlating with disease severity. Treatment normalizes these markers, suggesting complement plays a role in managing tuberculosis immune responses.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Clinical Chemistry

Background:

  • Pulmonary tuberculosis is associated with complex immune dysregulation.
  • Complement system activation is implicated in host defense and pathology during infection.

Purpose of the Study:

  • To investigate alterations in complement activity (CH50), complement components (C3, C3d), and circulating immune complexes (CICs) in pulmonary tuberculosis.
  • To correlate these changes with disease severity and treatment status.

Main Methods:

  • Serum/plasma samples from untreated tuberculosis patients, treated patients, and healthy controls were analyzed.
  • Levels of CH50, C3, C3d, and CICs were quantified.
  • Statistical analysis was performed to assess differences and correlations.

Related Experiment Videos

Main Results:

  • Mean levels of CH50, C3, C3d, and CICs were significantly higher in untreated patients compared to treated patients and controls.
  • Higher levels of CH50, C3d, and CICs were observed in untreated patients with far-advanced disease versus moderately advanced disease.
  • Significant correlations were found between CICs and C3/C3d in untreated patients, but not in treated patients.

Conclusions:

  • Elevated complement activation and CICs in untreated tuberculosis suggest a role in disease pathogenesis.
  • The complement system's functional classical pathway and proper activation by CICs may prevent tuberculosis from becoming a typical immune complex disease.