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The Skin Microbiota

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Related Experiment Video

Updated: May 26, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

The multitasking organ: recent insights into skin immune function.

Paola Di Meglio¹, Gayathri K Perera, Frank O Nestle

¹St. John's Institute of Dermatology, King's College London & National Institute for Health Research Biomedical Research Center, Guy's and St. Thomas's Hospitals, London SE1 9RT, UK.

|December 27, 2011

Summary

The skin acts as a vital defense system, integrating immunology and biology to maintain homeostasis. Its immune network and microbial interactions are crucial for responding to injury, infection, and autoimmune conditions like psoriasis.

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Last Updated: May 26, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

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Published on: March 25, 2016

Area of Science:

Cutaneous immunology
Skin biology
Microbiome research

Background:

The skin serves as the primary barrier against external threats.
Understanding skin's immune functions is critical for overall health.
The skin's microbiome plays a significant role in its immune responses.

Purpose of the Study:

To integrate current knowledge of cutaneous immunology and skin biology.
To highlight the skin's role as a multitasking organ in maintaining homeostasis.
To explore the interplay between the skin, its microbiome, and immune responses.

Main Methods:

Review and integration of recent findings in cutaneous immunology.
Analysis of fundamental concepts in skin biology.
Examination of crosstalk between skin and its microbial environment.
Investigation of targeted therapies for inflammatory skin conditions.

Main Results:

The skin functions as a dynamic organ essential for body homeostasis.
Specific skin-resident immune cell subsets possess distinct functions.
Microbial interactions significantly influence skin's response to injury, infection, and autoimmunity.
Psoriasis therapy offers insights into skin immune signaling pathways.

Conclusions:

The skin immune network is complex and multifaceted.
Understanding skin-immune-microbiome interactions is key to addressing inflammatory skin diseases.
A disease interactome for psoriasis can elucidate complex signaling pathways.