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Updated: May 26, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
[3-Bromo-meth-yl-1-(4-methyl-phenyl-sulfon-yl)azetidin-3-yl]methanol
Xiao-Qiang Guo1, Hu Zheng, Qing-Rong Qi
1Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C(12)H(16)BrNO(3)S, contains two independent mol-ecules. In each mol-ecule, the azetidine four-membered ring adopts a nearly planar conformation, the maximum deviations being 0.087 (3) and 0.079 (3) Å. The mean azetidine plane is twisted by 75.2 (2) and 73.6 (2)° with respect to the plane of the benzene ring in the two independent mol-ecules. The crystal packing is stabilized by O-H⋯O hydrogen bonds.
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