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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

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Updated: May 26, 2026

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

The hematopoietic stem cell niche.

Dongsu Park1, David B Sykes, David T Scadden

  • 1Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

Frontiers in Bioscience (Landmark Edition)
|December 29, 2011
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) rely on their specialized niche microenvironment for proper function. Understanding this niche is crucial for both basic science and clinical applications in hematopoiesis.

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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Microenvironment Research

Background:

  • Hematopoietic stem cells (HSCs) are crucial for blood cell formation.
  • HSC function is regulated by signals from their surrounding niche.
  • The HSC niche is a specialized microenvironment essential for HSC self-renewal and differentiation.

Purpose of the Study:

  • To review recent findings on the hematopoietic stem cell (HSC) niche.
  • To discuss unresolved questions regarding HSC niche function.
  • To examine the clinical implications of HSC niche knowledge.

Main Methods:

  • Literature review of recent studies on the HSC niche.
  • Analysis of cellular components and molecular factors within the niche.
  • Synthesis of current knowledge and identification of future research directions.

Main Results:

  • Recent studies have identified key cellular and molecular components of the HSC niche.
  • The microenvironment plays a critical role in regulating HSC behavior.
  • Understanding niche interactions is advancing rapidly.

Conclusions:

  • The hematopoietic stem cell (HSC) niche is a complex microenvironment vital for HSC function.
  • Further research into the HSC niche holds significant promise for clinical applications.
  • Continued investigation is needed to fully elucidate and exploit the HSC niche.