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Related Concept Videos

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Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
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Published on: January 14, 2021

Life is a pattern: vascular assembly within the embryo.

Jennifer Heinke1, Cam Patterson, Martin Moser

  • 1Department of Internal Medicine III, University of Freiburg, Germany.

Frontiers in Bioscience (Elite Edition)
|December 29, 2011
PubMed
Summary
This summary is machine-generated.

Vascular system development in embryos involves vasculogenesis and angiogenesis, regulated by cellular mechanisms and signaling pathways. Understanding these processes aids in treating adult diseases like cancer and ischemic conditions.

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Micropatterning and Assembly of 3D Microvessels
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Last Updated: May 26, 2026

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07:49

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Published on: January 14, 2021

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
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Micropatterning and Assembly of 3D Microvessels
13:05

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Published on: September 9, 2016

Area of Science:

  • Developmental biology
  • Molecular biology
  • Physiology

Background:

  • Embryonic organogenesis requires a vascular system for nutrient and oxygen transport.
  • Vascular formation involves two key processes: vasculogenesis and angiogenesis.
  • Complex cellular mechanisms and signaling pathways orchestrate vascular tree development.

Purpose of the Study:

  • To review the current understanding of major signaling pathways in embryonic vascular development.
  • To highlight the molecular mechanisms underlying vasculogenesis and angiogenesis.
  • To connect embryonic vascular development to therapeutic strategies for adult diseases.

Main Methods:

  • Review of existing literature on embryonic vascular development.
  • Analysis of key cellular mechanisms (migration, proliferation, differentiation, maturation).
  • Identification and description of critical signaling pathways involved.

Main Results:

  • Detailed overview of essential signaling pathways governing vascular formation.
  • Explanation of spatio-temporal coordination of these pathways.
  • Elucidation of cellular behaviors driving vascular development.

Conclusions:

  • Embryonic vascular development is a complex, multi-step process.
  • Signaling pathways are crucial for coordinated vascular growth.
  • Insights into embryonic angiogenesis inform therapies for ischemic diseases and cancer.