Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-World Effectiveness of the Peer-Led Honest, Open, Proud Programme for Self-Stigma Among Adults With Mental Illness: A Pragmatic, Multicentre, Randomised Controlled Trial.

The Lancet regional health. Europe·2026
Same author

The prevalence of insomnia disorder in inpatient psychiatric care.

European archives of psychiatry and clinical neuroscience·2026
Same author

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis.

International journal of dermatology·2026
Same author

Prevalence and associated factors of subjective cognitive decline (SCD Plus): a cross-sectional analysis of three population-based European cohorts.

Alzheimer's research & therapy·2026
Same author

Dupilumab therapy in atopic dermatitis when cutaneous lymphoma is suspected: Consensus recommendations from the EORTC Cutaneous Lymphoma Tumour Group.

The Journal of allergy and clinical immunology·2026
Same author

Rest Assured: The Association of Structural, Functional Support, and Loneliness With Subjective Sleep Health.

Journal of sleep research·2026
Same journal

Repositioning Non-Ablative Fractional Lasers - Molecular and Histological Insights from a scoping review.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Infusion-site reactions to foslevodopa/foscarbidopa in Parkinson's disease.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Tranexamic Acid-Soaked Intranasal Packing for Postoperative Bleeding After Nasal Interpolation Flap Repair.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Monoclonal gammopathy of dermatological significance: non-amyloid paraprotein deposits with light and heavy chains.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Papular epidermal nevus with "skyline" basal cell layer: Clinical clues from a three-member family.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

A single-center prospective observational study evaluating the efficacy and safety of tirbanibulin 1% in actinic keratoses in immunosuppressed patients: the ESTIMATE study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Primary cutaneous B-cell lymphomas.

Werner Kempf1, Natalja Denisjuk, Katrin Kerl

  • 1Department of Dermatology, University Hospital Zurich, Switzerland. werner.kempf@access.uzh.ch

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|January 4, 2012
PubMed
Summary
This summary is machine-generated.

Cutaneous B-cell lymphomas (CBCL) are common skin cancers. While some forms have an excellent prognosis, others require aggressive treatment, highlighting the need for accurate diagnosis.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Related Experiment Videos

Last Updated: May 26, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Cutaneous B-cell lymphomas (CBCL) represent the second most frequent primary cutaneous lymphomas.
  • The majority of CBCL cases include cutaneous follicle center lymphoma and cutaneous marginal zone lymphoma, typically presenting as nodules.

Purpose of the Study:

  • To differentiate between indolent and aggressive forms of CBCL.
  • To emphasize the diagnostic importance of clinico-pathologic correlation, histology, immunohistochemistry, genotyping, and staging.

Main Methods:

  • Review of clinical presentations and histopathological findings of CBCL.
  • Immunohistochemical profiling and genotyping for lymphoma subtyping.
  • Staging examinations to assess disease extent.

Main Results:

  • Cutaneous follicle center lymphoma and cutaneous marginal zone lymphoma exhibit an indolent course with a good prognosis, despite frequent recurrences.
  • Cutaneous diffuse large B-cell lymphoma, leg type, and other rare CBCL variants have a poor prognosis, necessitating multiagent chemotherapy and anti-CD20 monoclonal antibodies.

Conclusions:

  • Accurate diagnosis and classification of CBCL are critical for determining prognosis and guiding treatment strategies.
  • Distinguishing between indolent and aggressive CBCL subtypes is essential for patient management and therapeutic decisions.