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Published on: March 30, 2019
[Silica induce cell cycle changes by mitogen-activated protein kinases pathway].
Xiao-Wei Jia1, Bing-Ci Liu, Meng Ye
1National Institute of Occupation Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Summary
Mitogen-activated protein kinases (MAPK) influence silica-induced cell cycle changes. Specifically, ERK and JNK pathways mediate these alterations, impacting cell cycle progression in fibroblasts.
Area of Science:
- Cell Biology
- Molecular Biology
- Toxicology
Context:
- Silica exposure can induce cellular responses impacting cell cycle regulation.
- Mitogen-activated protein kinases (MAPK) are critical signaling pathways involved in cellular stress responses.
- Understanding silica's effects on cell cycle progression is crucial for assessing its toxicological impact.
Purpose:
- To elucidate the specific roles of MAPK signaling pathways in silica-induced cell cycle alterations.
- To identify which MAPK members (ERK, JNK, p38) are involved in silica's effects on cell cycle progression.
Summary:
- Human embryo lung fibroblasts treated with silica showed decreased G1 phase cell proportions.
- Dominant-negative mutants of ERK and JNK, but not p38, impaired silica-induced cell cycle changes.
- ERK and JNK signaling mediate silica-induced overexpression of cyclin D1 and CDK4, and decreased E2F-4 expression.
Impact:
- This study identifies ERK and JNK as key mediators of silica-induced cell cycle changes.
- Findings contribute to understanding the molecular mechanisms underlying silica toxicity.
- Provides insights into potential therapeutic targets for mitigating silica-induced cellular damage.
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