Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview01:32

Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview

Cyanohydrins are compounds that contain –CN and –OH groups on the same carbon atom. They are formed by the nucleophilic addition of the cyanide ions to the carbonyl group. Cyanide ions are highly basic and nucleophilic and can be generated from HCN under aqueous conditions. However, since HCN is a weak acid, the number of cyanide ions generated is very small. Hence, a small amount of base or KCN/NaCN is added to HCN to increase the concentration of the cyanide ions in the reaction mixture.
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A reference-based PET/MRI method for quantifying activation-induced changes in cerebral oxygen metabolism.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

An efficient 2,6-di(thiazol-2-yl)pyridine-based chemosensor for dual-response fluorometric and colorimetric detection of Fe<sup>2+</sup> and Cu<sup>2</sup>.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Hydrosilafluorenes as Recyclable Coupling Reagents for Direct Amidation of Carboxylic Acids with Amines.

Organic letters·2025
Same author

Cholinergic synaptic plasticity shapes resilience and vulnerability to tau.

bioRxiv : the preprint server for biology·2025
Same author

A facile route to <i>cis</i>-olefin-linked phosphino-phosphonium salts of the form: [Ph<sub>2</sub>PC(R)C(H)P(R')<sub>2</sub>H][AlCl<sub>4</sub>].

Chemical communications (Cambridge, England)·2025
Same author

SMART-PET: a Self-SiMilARiTy-aware generative adversarial framework for reconstructing low-count [18F]-FDG-PET brain imaging.

Frontiers in nuclear medicine·2024

Related Experiment Video

Updated: May 26, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
11:04

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

(E)-2-(2-Methyl-cyclo-hexyl-idene)hydrazinecarbothio-amide.

Justin W Hicks, Alan J Lough, Alan A Wilson

    Acta Crystallographica. Section E, Structure Reports Online
    |January 6, 2012
    PubMed
    Summary

    Molecules of C(8)H(15)N(3)S form chains via N-H⋯S hydrogen bonds in their crystal structure. An additional intramolecular N-H⋯N hydrogen bond is also observed within the crystal lattice.

    More Related Videos

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
    10:44

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

    Published on: April 19, 2019

    Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
    11:45

    Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

    Published on: August 22, 2018

    Related Experiment Videos

    Last Updated: May 26, 2026

    Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
    11:04

    Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

    Published on: June 13, 2022

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
    10:44

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

    Published on: April 19, 2019

    Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
    11:45

    Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

    Published on: August 22, 2018

    Area of Science:

    • Crystallography
    • Supramolecular Chemistry

    Background:

    • Hydrogen bonding plays a crucial role in molecular self-assembly and crystal engineering.
    • Understanding intermolecular interactions is key to predicting and controlling material properties.

    Purpose of the Study:

    • To elucidate the crystal structure of the title compound, C(8)H(15)N(3)S.
    • To identify and characterize the hydrogen bonding network within the crystal.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
    • Analysis of the crystal structure revealed the presence and geometry of hydrogen bonds.

    Main Results:

    • The crystal structure of C(8)H(15)N(3)S was successfully determined.
    • Molecules are linked by intermolecular N-H⋯S hydrogen bonds, forming one-dimensional chains along the [100] direction.
    • An intramolecular N-H⋯N hydrogen bond was also identified within individual molecules.

    Conclusions:

    • The hydrogen bonding network, specifically the N-H⋯S and N-H⋯N interactions, dictates the packing and chain formation in the crystal structure.
    • This structural information provides insights into the supramolecular assembly of this compound.