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Related Concept Videos

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview01:26

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview

Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
Nitrosation of Enols01:19

Nitrosation of Enols

The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.
Preparation of Nitriles01:12

Preparation of Nitriles

One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...

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1-(2,4-Di-nitro-phen-yl)-2-[(E)-2,4,5-tri-meth-oxy-benzyl-idene]hydrazine.

Acta crystallographica. Section E, Structure reports online·2013
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(E)-1-(2,4-Dinitro-phen-yl)-2-[1-(3-nitro-phen-yl)ethyl-idene]hydrazine.

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(E)-1-(2,4-Dinitro-phen-yl)-2-[1-(3-meth-oxy-phen-yl)ethyl-idene]hydrazine.

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(E)-1-(2,4-Dinitro-phen-yl)-2-[1-(3-fluoro-phen-yl)ethyl-idene]hydrazine.

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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

(E)-1-(2,4-Dinitro-phen-yl)-2-[1-(2-nitro-phen-yl)ethyl-idene]hydrazine.

Boonlerd Nilwanna, Suchada Chantrapromma, Patcharaporn Jansrisewangwong

    Acta Crystallographica. Section E, Structure Reports Online
    |January 6, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Researchers synthesized a novel compound, C(14)H(11)N(5)O(6), via a condensation reaction. Structural analysis revealed specific molecular conformations and intermolecular interactions, forming a 3D crystal network.

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    An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

    Published on: November 2, 2016

    Area of Science:

    • Organic Chemistry
    • Crystallography
    • Molecular Structure

    Background:

    • The synthesis of novel organic compounds is crucial for materials science.
    • Understanding molecular conformation and crystal packing is key to predicting material properties.

    Purpose of the Study:

    • To synthesize and characterize a new compound derived from 2,4-dinitro-phenyl-hydrazine and 2-nitro-acetophenone.
    • To elucidate the molecular structure, including conformation and hydrogen bonding.
    • To investigate the crystal packing and intermolecular interactions.

    Main Methods:

    • Condensation reaction between 2,4-dinitro-phenyl-hydrazine and 2-nitro-acetophenone.
    • Single-crystal X-ray diffraction analysis.
    • Analysis of molecular geometry, hydrogen bonding, and π-π stacking interactions.

    Main Results:

    • The title compound, C(14)H(11)N(5)O(6), was successfully synthesized.
    • The molecule exhibits an E conformation around the C=N bond and an intramolecular N-H⋯O hydrogen bond forming an S(6) ring.
    • Crystal structure analysis revealed a 3D network formed by C-H⋯O hydrogen bonds and π-π stacking interactions with a centroid-centroid distance of 3.6447(8) Å.
    • The dihedral angle between the benzene rings is 7.84(6)°.

    Conclusions:

    • The study successfully synthesized and characterized a novel organic compound.
    • The determined crystal structure provides insights into intermolecular forces governing the solid-state arrangement.
    • The findings contribute to the understanding of structure-property relationships in organic materials.