Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reversible one-step acylation facilitates mitochondrial delivery of functional RNA.

Chemical science·2026

Same author

Targeting AVEN Liquid-Liquid Phase Separation in Colorectal Cancer: Insights From a Raddeanin A-Based Chemical Probe.

Basic & clinical pharmacology & toxicology·2026

Same author

From defense to reconstruction: The hostility-meaning dual-path model of how observing others' adversity influences distress disclosure.

PloS one·2026

Same author

Perceptions of Factors Associated With Sustainability of Evidence-Based Nursing Practice: A Sequential Mixed Methods Study.

Journal of nursing management·2026

Same author

SPECTRAL: An Intelligent and Ultra-Sensitive Photonic Hydrogel Platform for Biomarker-Based Cancer Prediction.

Angewandte Chemie (International ed. in English)·2026

Same author

Lipoprotein lipase facilitates Aβ transport across the blood-brain barrier via LRP1: Validation of the obesity paradox in Alzheimer's disease.

Journal of advanced research·2026

Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026

Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026

Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026

Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026

Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026

Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 26, 2026

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Published on: November 13, 2017

Current advances in peptide and small molecule microarray technologies.

Yu M Foong¹, Jiaqi Fu, Shao Q Yao

¹Department of Biological Science, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.

Current Opinion in Chemical Biology

|January 7, 2012

Summary

This summary is machine-generated.

Microarray technology enables high-throughput screening for drug discovery and disease research. Recent advances in small molecule and peptide microarrays are expanding their applications in biology and medicine.

More Related Videos

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

Related Experiment Videos

Last Updated: May 26, 2026

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Published on: November 13, 2017

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

Area of Science:

Biotechnology
Chemical Biology
Genomics

Background:

Microarrays provide a powerful platform for massively parallel screening.
Historically focused on small molecule screening, microarrays now aid in disease biology and cellular state analysis.

Purpose of the Study:

To review recent advancements in small molecule and peptide microarray technology.
To highlight innovative applications and future potential of microarrays in biological research.

Main Methods:

Review of current literature on microarray synthesis and fabrication.
Analysis of emerging trends in library design and diversity for peptide and small molecule microarrays.

Main Results:

Microarray applications have expanded beyond target-centric screening to complex biological studies.
Innovations in synthesis and immobilization strategies have broadened fabrication methods.
Diverse libraries are crucial for the success of peptide and small molecule microarrays.

Conclusions:

Microarray technology continues to evolve, offering new methods for high-throughput analysis.
Future breakthroughs are anticipated in the application of small molecule and peptide microarrays.
The field is poised for significant advancements in the next decade.