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Updated: May 26, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts
Published on: June 8, 2010
Trophoblast development
Peter L Pfeffer1, David J Pearton
1Reproductive Technologies, AgResearch Crown Research Institute, Hamilton 3204, New Zealand. peter.pfeffer@agresearch.co.nz
Abstract:
This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies, in vivo loss-of-function models and in vitro systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.
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