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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
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Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

Single-molecule surface-enhanced Raman spectroscopy.

Eric C Le Ru1, Pablo G Etchegoin

  • 1The MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical and Physical Sciences, Victoria University of Wellington, New Zealand. eric.leru@vuw.ac.nz

Annual Review of Physical Chemistry
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) is now a robust technique, enabling the observation of previously inaccessible phenomena like isotopic substitutions and homogeneous peak broadening in individual molecules.

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Area of Science:

  • Spectroscopy
  • Surface-Enhanced Raman Spectroscopy (SERS)

Background:

  • Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) has overcome past debates to become a well-established field.
  • The technique allows for the observation of subtle spectroscopic phenomena previously inaccessible.

Purpose of the Study:

  • To provide a comprehensive overview of the current state of single-molecule surface-enhanced Raman spectroscopy (SM-SERS).
  • To highlight recent developments and future directions in SM-SERS, incorporating examples from the authors' group and others.

Main Methods:

  • Review of established and emerging techniques within single-molecule surface-enhanced Raman spectroscopy.
  • Analysis of key phenomena observable through SM-SERS, including isotopic substitutions and Raman excitation profiles.

Main Results:

  • SM-SERS enables the observation of natural isotopic substitutions in single molecules.
  • The technique allows for the study of true homogeneous broadening of Raman peaks and Raman excitation profiles of individual molecules.
  • SM electrochemistry is presented as a novel application within the field.

Conclusions:

  • Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) is a rapidly advancing and validated spectroscopic technique.
  • SM-SERS offers unprecedented insights into molecular behavior at the single-molecule level, opening new avenues for research.