Related Experiment Video
Updated: May 26, 2026

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
Published on: March 30, 2022
Enkephalin degrading enzymes: metalloproteases with high potential for drug development
Tejinder Pal Khaket1, Jasbir Singh, Pooja Attri
1Department of Biochemistry, Kurukshetra University, India.
Abstract:
Enkephalins play a great role in management of pain, blood pressure, hypertension and cardiovascular diseases. Enkephalins are short-lived molecules being rapidly hydrolyzed following their synaptic release by enkephalin degrading enzymes. The inhibitors of enkephalin degrading enzymes are able to prolong the duration of action of enkephalins. This review will focus on the inhibitors of enkephalin degrading enzymes as a novel therapeutic approach for cancer itself and also in cancer and neuropathic pain management with discussion on the present status and future directions for a new class of drugs.
Related Concept Videos
Role of Matrix Metalloproteases in Degradation of ECM
A...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Lysosomal Hydrolases
Microbial Bioremediation of Plastics
The Proteasome
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...

