Animal models of overeating.

Area of Science:

• Preclinical research
• Animal models in obesity research

Background:

• Obesity presents a significant global health and economic challenge.
• Urgent need for novel therapeutic strategies to combat obesity.

Purpose of the Study:

• To describe essential rat and mouse models for obesity research.
• To guide the selection of appropriate models based on research questions.
• To identify potential procedural challenges in preclinical obesity studies.

Main Methods:

• Focus on diet-induced obesity models in rodents (rats and mice).
• Examination of models simulating binge-eating behaviors.
• Discussion of model selection criteria and procedural considerations.

Main Results:

• Rats and mice are predominant species in preclinical obesity studies.
• Specific protocols for diet-induced obesity and binge eating are detailed.
• Guidance is provided on choosing between different models for specific research aims.

Conclusions:

• Appropriate animal model selection is critical for advancing obesity treatment development.
• Understanding model-specific methodologies and pitfalls enhances preclinical study validity.
• These models offer valuable insights for human obesity research.