Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of Amphibian Metamorphosis on the Biokinetics and Biodistribution of Radionuclides Cesium and Strontium.

Environmental science & technology·2026
Same author

Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation.

Frontiers in synaptic neuroscience·2026
Same author

MedTsLLM: Medical Time Series Analysis Using Multimodal LLMs.

IEEE journal of biomedical and health informatics·2025
Same author

Structural plasticity in the motor cortex: Differential impacts of learning and Li-iTBS on dendritic spine dynamics.

Neuroscience·2025
Same author

Comparing Ventral Hernia Repair Outcomes in Patients With and Without Liver Insufficiency.

Journal of the American College of Surgeons·2025
Same author

Technology Matters: A model for translating digital and data science innovations into Child and Adolescent Mental Health Services.

Child and adolescent mental health·2025

Related Experiment Video

Updated: May 26, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

The old and new methods of assessing kidney function.

Jessica L Steffl1, William Bennett, Ali J Olyaei

  • 1Division of Nephrology and Hypertension, Oregon State University and Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code CR9-4, Portland, OR 97201, USA.

Journal of Clinical Pharmacology
|January 11, 2012
PubMed
Summary

Estimating kidney function is crucial for managing chronic kidney disease and dosing medications. Different formulas for calculating glomerular filtration rate (GFR) show significant variations, but their clinical impact remains uncertain.

More Related Videos

Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

Related Experiment Videos

Last Updated: May 26, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

Area of Science:

  • Nephrology
  • Pharmacology
  • Biostatistics

Background:

  • Chronic kidney disease (CKD) is a global health concern requiring accurate kidney function assessment.
  • Glomerular filtration rate (GFR) is a key indicator of kidney health, vital for staging CKD and guiding drug dosages.
  • Measured GFR is accurate but impractical; estimated GFR (eGFR) equations using serum creatinine are widely used.

Purpose of the Study:

  • To evaluate the differences between various eGFR equations.
  • To determine if observed statistical differences in eGFR estimations translate to clinically significant variations in drug dosing.

Main Methods:

  • Comparison of creatinine clearance and eGFR calculations using established formulas.
  • Analysis of statistically significant differences in eGFR estimates across diverse populations.
  • Review of potential discrepancies in drug-dosing adjustments based on different eGFR equations.

Main Results:

  • Statistically significant differences were observed in eGFR estimations among the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.
  • These variations in eGFR may lead to differing drug-dosing recommendations.
  • Clinical outcome data is lacking to confirm the significance of these dosing differences.

Conclusions:

  • Current eGFR equations provide statistically different estimates of kidney function.
  • The clinical significance of these differences for patient outcomes and drug dosing requires further investigation.
  • More research is needed to validate the clinical utility of various eGFR estimation methods.