Related Experiment Video
Updated: May 26, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid
Dong Wuk Kim1, Jun Hyeok Kang, Dong Hoon Oh
1College of Pharmacy, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
Journal of Microencapsulation
|January 12, 2012
Summary
This study developed a novel flurbiprofen-loaded solid self-microemulsifying drug delivery system (solid SMEDDS) using gelatin. The new formulation significantly enhanced flurbiprofen
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Poorly water-soluble drugs often exhibit low oral bioavailability.
- Self-microemulsifying drug delivery systems (SMEDDS) can enhance drug solubility and absorption.
- Solid SMEDDS offer advantages in handling and stability compared to liquid formulations.
Purpose of the Study:
- To develop a novel flurbiprofen-loaded solid SMEDDS using gelatin as a carrier.
- To improve the oral bioavailability of flurbiprofen.
- To investigate the characteristics of the developed solid SMEDDS.
Main Methods:
- Liquid SMEDDS were prepared using specific excipients and flurbiprofen.
- Solid SMEDDS were formulated by spray-drying liquid SMEDDS with gelatin.
- Particle size analysis was performed on liquid and solid SMEDDS.
- The oral bioavailability of flurbiprofen was evaluated in rats.
Main Results:
- Liquid SMEDDS had a z-average diameter of approximately 100 nm.
- The solid SMEDDS formed microcapsules with the gelatin carrier.
- Flurbiprofen remained in an amorphous state within the solid SMEDDS.
- A significant improvement in the oral bioavailability of flurbiprofen was observed in rats.
Conclusions:
- Gelatin is a suitable carrier for developing solid SMEDDS.
- The developed solid SMEDDS formulation effectively enhances the oral bioavailability of flurbiprofen.
- This approach holds promise for improving the delivery of other poorly water-soluble drugs.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:19Modified-Release Drug Delivery Systems: Overview
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...