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Updated: May 25, 2026
11:36
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Ornidazole-induced autoimmune hepatitis.
Galip Ersöz1, Rukiye Vardar, Ulus Salih Akarca
1Department of Gastroenterology, Ege University, School of Medicine, İzmir, Turkey.
Summary
Ornidazole can cause drug-induced autoimmune hepatitis in women. Drug withdrawal may not be enough for recovery, suggesting immunosuppressive therapy may be needed for this liver injury.
Area of Science:
- Hepatology
- Immunology
- Pharmacology
Background:
- Drug-induced liver injury (DILI) can mimic autoimmune hepatitis (AIH).
- The role of drugs and herbs in unmasking or inducing AIH versus causing DILI with autoimmune features remains unclear.
- Ornidazole is a potential cause of drug-induced hepatitis with autoimmune features.
Observation:
- Eight female patients presented with acute hepatitis and were diagnosed with drug-induced autoimmune hepatitis.
- Exclusion criteria included viral hepatitis, metabolic, vascular, biliary, or alcohol-related liver disease.
- Autoimmune hepatitis scores were calculated using International Autoimmune Hepatitis Group criteria.
Findings:
- All eight patients were diagnosed with drug-induced autoimmune hepatitis.
- Seven patients were treated with prednisolone and azathioprine.
- Liver biopsy scoring by Ishak et al. was used.
Implications:
- Ornidazole can induce autoimmune hepatitis.
- Discontinuation of ornidazole may not lead to recovery.
- Immunosuppressive therapy may be necessary for ornidazole-induced autoimmune hepatitis.
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