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(153)Sm-EDTMP appears to accumulate only trivially within peritoneal ascites
Gene A Schreck1, Ryan D Niederkohr
1Department of Nuclear Medicine, Kaiser Permanente Medical Center, Santa Clara, California, USA.
Journal of Nuclear Medicine Technology
|January 12, 2012
Summary
Samarium-153 lexidronam (EDTMP) is used for bone metastases pain. This study measured (153)Sm-EDTMP accumulation in malignant ascites, finding minimal levels, which is important for nuclear medicine practitioners.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiopharmaceutical Therapy
Background:
- Samarium-153 lexidronam ((153)Sm-EDTMP) is a radiopharmaceutical for palliative care of bone pain from metastatic disease.
- Malignant ascites is a common complication in patients with advanced cancer.
Observation:
- A patient with extensive osseous metastases and malignant ascites was treated with (153)Sm-EDTMP.
- No prior data existed on (153)Sm-EDTMP accumulation in ascites fluid.
Findings:
- The ratio of (153)Sm-EDTMP activity in 1.71 L of peritoneal fluid to the injected dose was measured.
- The measured ratio was 0.01%, indicating minimal accumulation in the ascites fluid.
Implications:
- This is the first published measurement of (153)Sm-EDTMP accumulation in peritoneal fluid.
- Findings are relevant for nuclear medicine professionals managing cancer patients with ascites receiving (153)Sm-EDTMP therapy.
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