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Effect of zinc chloride on picrotoxin-induced hyperkinesis depends on its concentration in solution injected into rat
A F Yakimovskii1, I I Stepanov
1Department of Normal Physiology, St. Petersburg State I. P. Pavlov Medical University, St. Petersburg, Russia. jakim@spmu.rssi.ru
Abstract:
The hyperkinekic effect (increase in spontaneous activity and development of choreomyoclonic hyperkinesis of the extremities and body) of picrotoxin injected into the rostral neostriatum of rats in a dose of 2 μg was reduced if the drug was injected together with ZnCl(2) in a concentration of 0.1 μg/μl. ZnCl(2) in a concentration of 1 μg/μl did not modulate the effects of picrotoxin, while in a concentration of 3 μg/μl it increased spontaneous motor activity in the open field test without affecting the symptoms of choreomyoclonic hyperkinesis.
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