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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Updated: May 25, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
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Published on: April 25, 2014

The TDR Tuberculosis Strain Bank: a resource for basic science, tool development and diagnostic services.

V Vincent1, L Rigouts, E Nduwamahoro

  • 1United Nations Children's Fund/United Nations Development Programme/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|January 13, 2012
PubMed
Summary
This summary is machine-generated.

The new Mycobacterium tuberculosis strain bank offers 229 clinical isolates and reference strains, characterized for drug resistance and genetic lineage. This bioresource supports development of new diagnostics and quality control for tuberculosis research.

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Area of Science:

  • Microbiology
  • Genetics
  • Drug Resistance Research

Background:

  • The Special Programme for Research and Training in Tropical Diseases established the Mycobacterium tuberculosis strain bank (TDR-TB Strain Bank).
  • This initiative aims to centralize and characterize M. tuberculosis isolates for research purposes.

Purpose of the Study:

  • To detail the TDR-TB Strain Bank's collection, strain characterization methods, management protocols, and material release procedures.
  • To provide a comprehensive overview of this valuable research resource.

Main Methods:

  • Characterization of 229 clinical M. tuberculosis isolates and 5 reference strains.
  • Assessment of drug resistance profiles using minimum inhibitory concentrations for multiple first- and second-line drugs.
  • Sequencing of key genes (e.g., rpoB, katG, gyrA) to identify drug resistance mutations.
  • Genetic lineage determination using mycobacterial interspersed repetitive unit-variable number tandem repeat typing.

Main Results:

  • The TDR-TB Strain Bank contains 229 clinical M. tuberculosis isolates and 5 reference strains.
  • Strains are available as viable freeze-dried cultures or heat-inactivated suspensions, with quality control for purity and viability.
  • Isolates represent diverse geographical origins and varying drug resistance patterns, including low and high resistance levels.
  • Genetic lineage analysis confirmed the representation of major M. tuberculosis lineages.

Conclusions:

  • The TDR-TB Strain Bank serves as a high-quality bioresource for fundamental research.
  • It supports the development of novel diagnostics and tools for detecting drug-resistant tuberculosis.
  • The bank provides essential reference materials for laboratory quality management programs.