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Updated: May 25, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Aging of human muscle: understanding sarcopenia at the single muscle cell level
Walter R Frontera1, Ana Rodriguez Zayas, Natividad Rodriguez
1Department of Physical Medicine and Rehabilitation, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA. walter.frontera@upr.edu
Abstract:
The loss of muscle mass with age, also known as sarcopenia, is a major scientific and public health problem. Muscle atrophy is associated with the loss of functional capacity and poor health outcomes in elderly men and women. A detailed understanding of this problem in humans can be enhanced by the use of experiments with single muscle fibers. It is likely that both muscle atrophy and a decrease in muscle-fiber quality contribute to muscle dysfunction among the elderly. A better understanding of sarcopenia at the single-fiber level may lead to the design of more effective rehabilitative interventions.
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