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Published on: April 14, 2011
[Children hospitalized with influenza pneumonia AH1N1/2009 pandemic in the INSN]
Edwin Miranda-Choque1, Carlos Ramírez, Jorge Candela-Herrera
1Servicio de Infectología, Instituto Nacional de Salud del Niño, Lima, Perú. emirandach@hotmail.com
Insights
Nosocomial viral pneumonia (NVP) cases during the 2009 H1N1 pandemic had higher mortality, particularly in children with pre-existing conditions. Early identification and intervention are crucial for managing severe influenza A H1N1 pneumonia.
Area of Science:
- Pediatric Infectious Diseases
- Virology
- Epidemiology
Context:
- The 2009 influenza A H1N1 pandemic posed a significant threat to child health.
- Pneumonia is a major complication of influenza, especially in pediatric populations.
- Understanding the characteristics of H1N1-associated pneumonia is vital for clinical management.
Purpose:
- To characterize the clinical and demographic features of children hospitalized with H1N1 pandemic influenza A virus (A H1N1/2009) pneumonia.
- To identify risk factors associated with severe outcomes, including mortality and mechanical ventilation.
- To differentiate between community-acquired and nosocomial viral pneumonia in the context of the H1N1 pandemic.
Summary:
- A retrospective study of 74 children with confirmed A H1N1/2009 influenza pneumonia revealed distinct patterns.
- Nosocomial viral pneumonia (NNv) cases demonstrated a statistically significant association with mortality, especially in children with pre-existing conditions like malnutrition and congenital heart disease.
- Community-acquired viral pneumonia (NACv) predominantly affected children under 6 years, with fever, cough, and runny nose as common symptoms. Elevated C-reactive protein (CRP) levels correlated with respiratory failure.
Impact:
- This study highlights the increased mortality risk associated with nosocomial viral pneumonia during the A H1N1/2009 pandemic.
- Findings underscore the importance of recognizing pre-existing conditions as critical factors influencing outcomes in pediatric influenza pneumonia.
- The data provides valuable insights for public health strategies and clinical protocols aimed at mitigating severe influenza A H1N1 pneumonia in children.
Objective:
To determine the clinical and demographic characteristics of pneumonia with influenza virus AH1N1/2009 pandemic at the National Institute of Child.
Methods:
Retrospective case series in children hospitalized for influenza pneumonia pandemic AH1N1/2009 in a pediatric hospital. Reviewed the medical records between the months of June to September 2009. All cases had virological confirmation, we describe the clinical characteristics and conditions of severity.
Results:
A total of 74 children of pneumonia with influenza virus AH1N1/2009 pandemic (NVIp), of those 50 were community acquire pneumonia viral (NACv) and 24 pneumonia nosocomial viral (NNv), 16 required mechanical ventilation. 12 died, all had preexisting factors. NN cases showed statistical association with mortality. The most frequent factors were malnutrition, respiratory infections, congenital heart disease and neurological deficits In NACv cases the children under 6 years accounted for 72% (36/50). The median disease duration was 5 days. The most frequent symptoms were fever, cough, runny nose. Received oseltamivir 82%. The chest radiograph 48% of cases showed patchy infiltrates and 44% interstitial infiltrate on chest radiograph. Protein c reactive (CRP) more than 10mg / L was significantly associated with respiratory failure (p <0.05).
Conclusions:
Cases of NN found who had more mortality, even those who had the highest PCR and those with preexisting condition.
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