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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

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Related Experiment Video

Updated: May 25, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Food-induced anaphylaxis.

Antonella Cianferoni1, Antonella Muraro

  • 1Allergy and Immunology Division, The Children's Hospital of Philadelphia, University of Pennsylvania, ARC 1216H, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. cianferonia@email.chop.edu

Immunology and Allergy Clinics of North America
|January 17, 2012
PubMed
Summary
This summary is machine-generated.

Food-induced anaphylaxis (FIA) is a severe allergic reaction with increasing hospital admissions. Prompt allergen avoidance and epinephrine are critical for managing this life-threatening condition.

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Last Updated: May 25, 2026

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine
  • Public Health

Background:

  • Food-induced anaphylaxis (FIA) is a severe, potentially fatal allergic reaction.
  • Definitions and diagnostic criteria for FIA lack universal consensus.
  • Hospital admissions for FIA have significantly increased over the past decade.

Purpose of the Study:

  • To summarize the current understanding of food-induced anaphylaxis.
  • To highlight the prevalence and common triggers of FIA.
  • To emphasize the importance of management strategies for FIA.

Main Methods:

  • Literature review of existing surveys and studies on food-induced anaphylaxis.
  • Analysis of trends in hospital admissions for FIA.
  • Identification of common food allergens associated with anaphylaxis.

Main Results:

  • Food allergens account for 30-50% of all anaphylaxis cases.
  • Peanut, tree nuts, milk, eggs, sesame, fish, and shellfish are the most frequent culprits.
  • The incidence of FIA is on the rise, with a documented doubling of hospitalizations.

Conclusions:

  • Effective management of food-induced anaphylaxis relies on strict allergen avoidance.
  • Emergency treatment with epinephrine is essential for resolving anaphylactic events.
  • Further research is needed to standardize FIA diagnosis and improve public health strategies.