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Oncogenic potential of yin yang 1 mediated through control of imprinted genes

Michelle M Thiaville1, Joomyeong Kim

  • 1Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Critical Reviews in Oncogenesis
|January 18, 2012
PubMed

Insights

The transcription factor Yin Yang 1 (YY1) regulates imprinted genes. Altered YY1 levels in tumors may impact cancer development by changing the expression of these genes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The transcription factor Yin Yang 1 (YY1) is a highly conserved DNA-binding protein with ubiquitous expression.
  • YY1 acts as a crucial regulator for numerous genes, but its precise role in cancer remains unclear.
  • Recent findings indicate YY1 binding sites are enriched in imprinted gene loci, suggesting a regulatory role.

Purpose of the Study:

  • To explore the mechanisms by which YY1 influences imprinted gene expression in the context of cancer.
  • To investigate the potential impact of YY1 protein level fluctuations on cancer development and progression.

Main Methods:

  • This review synthesizes current research on YY1's function and its association with imprinted genes.
  • Analysis of existing studies linking YY1 levels, imprinted gene transcription, and tumor tissues.

Main Results:

  • YY1 binding sites are frequently found clustered in imprinted gene regions.
  • YY1 protein levels are altered in various tumor types.
  • Changes in YY1 levels correlate with the transcriptional status of regulated imprinted genes.

Conclusions:

  • Fluctuations in YY1 protein levels may act as a molecular rheostat, affecting imprinted gene expression.
  • This regulatory mechanism involving YY1 and imprinted genes could play a significant role in cancer initiation and progression.

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