Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in intratumor pH by two heatings.

J C Lin1, C W Song

  • 1Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota, Minneapolis 55455.

Cancer Research
|November 15, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scanning Tissue Oxygen Needle Probe.

Advances in experimental medicine and biology·2021
Same author

Diamine Functionalized Cubic Mesoporous Silica for Ibuprofen Controlled Delivery.

Journal of nanoscience and nanotechnology·2015
Same author

The effects of surface roughness of composite resin on biofilm formation of Streptococcus mutans in the presence of saliva.

Operative dentistry·2012
Same author

Tumour oxygenation is increased by hyperthermia at mild temperatures. 1996.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2009
Same author

Toxicity of repeated intravenous injection of gene therapeutics for X-CGD in mice.

Human & experimental toxicology·2008
Same author

COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia.

British journal of cancer·2007

Tumor heating typically lowers pH, but prior mild heating can make tumor vessels resistant. Subsequent intense heating fails to decrease intratumor pH due to this developed vascular thermotolerance.

Area of Science:

  • Oncology
  • Hyperthermia Therapy
  • Tumor Microenvironment

Background:

  • Tumor pH reduction after heating is linked to blood circulation breakdown.
  • Tumor blood vessels can develop thermotolerance after sublethal thermal doses.
  • Understanding vascular thermotolerance is crucial for optimizing hyperthermia treatments.

Purpose of the Study:

  • To investigate if heating can decrease intratumor pH when tumor vasculature exhibits thermotolerance.
  • To determine the impact of prior sublethal heating on the efficacy of subsequent hyperthermia in altering tumor pH.

Main Methods:

  • Utilized SCK tumors in A/J mice.
  • Assessed tumor vascular thermotolerance using the 86Rb uptake method at 18 hours post-initial heating.
  • Measured intratumor pH before and after hyperthermia treatments.

Related Experiment Videos

Main Results:

  • A single heating at 44.5°C for 1 hour significantly reduced intratumor pH from 7.05 to 6.70.
  • Tumor vessels showed maximal thermotolerance 18 hours after a 42.5°C, 1-hour pre-heating.
  • A second heating at 44.5°C for 1 hour failed to lower intratumor pH when vessels were thermotolerant.

Conclusions:

  • Vascular thermotolerance developed after initial heating prevents pH reduction by subsequent hyperthermia.
  • The failure to induce tumor acidity suggests hyperthermia efficacy is compromised by vascular adaptation.
  • This finding highlights the importance of considering vascular thermotolerance in hyperthermia treatment protocols.