Diamine Functionalized Cubic Mesoporous Silica for Ibuprofen Controlled Delivery

Area of Science:

• Materials Science
• Nanotechnology
• Drug Delivery

Background:

• Mesoporous silica materials like KIT-6 are promising for drug delivery applications.
• Functionalization of mesoporous silica can enhance its adsorption and release properties.

Purpose of the Study:

• To synthesize and characterize diamine functionalized KIT-6 (N-KIT-6) mesoporous silica.
• To evaluate the potential of N-KIT-6 for controlled drug delivery using ibuprofen (IBU) as a model drug.

Main Methods:

• Post-synthetic functionalization of calcined KIT-6 with N-[3-(trimethoxysilyl)-propyl]ethylenediamine.
• Characterization using Small-Angle X-ray Scattering (SAXS), N2 sorption, FT-IR, SEM, TEM, and TGA.
• Monitoring ibuprofen adsorption and release rates using UV-Vis spectrophotometry.

Main Results:

• Successful synthesis of N-KIT-6 with confirmed diamine groups and preserved mesoporous structure.
• N-KIT-6 exhibited higher ibuprofen adsorption and release rates compared to unmodified KIT-6.
• Enhanced performance attributed to N-KIT-6's increased hydrophobicity and abundant surface basic sites.

Conclusions:

• Diamine functionalization is an effective strategy to improve the drug delivery capabilities of KIT-6.
• N-KIT-6 demonstrates significant potential as a carrier for controlled drug release systems.
• The modified material offers advantages for enhanced drug loading and release kinetics.