Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but this inhibition is released...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Spare Receptors01:30

Spare Receptors

Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of low nitrate/nitrite diet and nitrate supplementation on litter size and fetal and placental growth in pregnant mice.

Nitric oxide : biology and chemistry·2025
Same author

Assessing Placental Dysfunction Subtypes in Pregnancies With a Low PlGF Centile.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Commentary on: "Long-term cardiovascular repercussions in women with previous pregnancies complicated by severe hypertensive disease".

Journal of hypertension·2025
Same author

Commentary on: 'Finger pulse plethysmography predicts gestational hypertension, preeclampsia and gestational diabetes'.

Journal of hypertension·2024
Same author

Investigating the association between nitrate dosing and nitrite generation by the human oral microbiota in continuous culture.

Applied and environmental microbiology·2024
Same author

RISING STARS: Bumps and bacteria: influence of the maternal microbiota on pregnancy outcomes.

The Journal of endocrinology·2024
Same journal

Endothelial Cell Phenotypic Plasticity in Atherosclerosis.

Handbook of experimental pharmacology·2026
Same journal

Endothelial Dysfunction and Neurovascular Alterations in Autism Spectrum Disorder.

Handbook of experimental pharmacology·2026
Same journal

Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease.

Handbook of experimental pharmacology·2026
Same journal

Microvasculature of the Pancreatic Islets of Langerhans in Health and Diabetes.

Handbook of experimental pharmacology·2026
Same journal

Mechanisms of Actions of Physiological, Pharmacological, and Toxicological Dietary Bioactive Inorganic Boron.

Handbook of experimental pharmacology·2026
Same journal

BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design.

Handbook of experimental pharmacology·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
09:29

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation

Published on: August 4, 2023

Leptin receptors.

Elizabeth C Cottrell1, Julian G Mercer

  • 1Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Scotland, EH16 4TH, UK.

Handbook of Experimental Pharmacology
|January 18, 2012
PubMed
Summary
This summary is machine-generated.

Leptin resistance, common in obesity, impairs leptin receptor signaling, driving further weight gain. Therapeutic strategies targeting leptin receptors are crucial for managing obesity and related metabolic disorders.

More Related Videos

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
10:47

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins

Published on: July 1, 2011

Related Experiment Videos

Last Updated: May 25, 2026

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
09:29

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation

Published on: August 4, 2023

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
10:47

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins

Published on: July 1, 2011

Area of Science:

  • Neuroendocrinology
  • Obesity Research
  • Metabolic Regulation

Background:

  • Leptin, a hormone from adipose tissue, regulates energy balance and reproduction.
  • Leptin or leptin receptor mutations cause rare genetic obesity with hyperphagia.
  • Most human obesity involves elevated leptin (hyperleptinemia) and leptin resistance.

Purpose of the Study:

  • To review the critical role of leptin receptors in controlling feeding behaviors.
  • To examine how leptin receptor function impacts obesity development.
  • To discuss the therapeutic potential and challenges of targeting leptin receptors.

Main Methods:

  • Review of existing literature on leptin, leptin receptors, and obesity.
  • Analysis of the distribution and function of leptin receptors in the central nervous system (CNS) feeding circuitry.
  • Evaluation of current and potential pharmacological interventions for leptin receptor modulation.

Main Results:

  • Leptin receptors are present in key CNS areas regulating feeding, including the brainstem and hypothalamus.
  • Leptin signaling via its receptors influences feeding behaviors by integrating signals within CNS circuits.
  • Leptin resistance, particularly with high-fat diets, curtails receptor signaling and exacerbates obesity.

Conclusions:

  • Leptin receptors are central to regulating appetite and energy homeostasis.
  • Targeting leptin receptors offers a potential therapeutic avenue for obesity, though challenges remain.
  • Current treatments show promise with peptide analogues, but small molecule interventions for leptin receptors are still under development.