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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Published on: February 13, 2016

Engineering nanomedicines using stimuli-responsive biomaterials.

Yapei Wang1, James D Byrne, Mary E Napier

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, 27599, USA.

Advanced Drug Delivery Reviews
|January 24, 2012
PubMed
Summary
This summary is machine-generated.

Particle engineering offers new medicines and diagnostics. This study explores scalable methods for creating shape-specific particles using stimuli-responsive biomaterials for controlled drug delivery, focusing on PRINT technology.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Particle engineering is crucial for developing advanced medicines and diagnostics.
  • Precise control over particle properties (size, shape, surface chemistry) accelerates translation and regulatory approval.
  • Stimuli-responsive materials enable triggered drug release for enhanced therapeutic control.

Purpose of the Study:

  • To examine scalable top-down fabrication methods for shape-specific particles.
  • To highlight the use of stimuli-responsive biomaterials in controlled drug delivery.
  • To focus on Particle Replication In Nonwetting Templates (PRINT®) technology and novel polymers.

Main Methods:

  • Utilizing top-down fabrication techniques for particle synthesis.
  • Employing stimuli-responsive natural and synthetic polymers.
  • Investigating Particle Replication In Nonwetting Templates (PRINT®) technology.

Main Results:

  • Demonstrated scalable methods for fabricating shape-specific particles.
  • Showcased the potential of stimuli-responsive materials for controlled release.
  • Highlighted the applicability of PRINT® technology in particle fabrication.

Conclusions:

  • Scalable particle fabrication using stimuli-responsive biomaterials is feasible.
  • PRINT® technology offers a promising platform for controlled drug delivery applications.
  • Engineered particles hold significant potential for treating major diseases.