Related Experiment Video
Updated: May 25, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Vascular endothelial growth factor and type 2 receptor for this factor in vascular malformations
K A Pavlov1, E S Gershtein, E A Dubova
1V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. pavlovkos@gmail.com
Abstract:
Immunohistochemical study revealed higher level of VEGF expression in vascular malformations compared to that in normal vessels of the adjacent tissue. VEGF expression was slightly higher in the endothelium of arteriovenous angiodysplasias than in venous angiodysplasias. Enzyme immunoassay of tissue extracts showed that the concentrations of VEGF and VEGFR2 differ in arteriovenous and venous malformations. The concentrations of VEGF and VEGFR2 differed more significantly in primary and recurrent forms of arteriovenous angiodysplasias (as compared to venous angiodysplasias).
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Mechanism of Angiogenesis
Mitogens and the Cell Cycle
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

