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Updated: May 25, 2026

Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
Auto-immune cholangiopathy in a juvenile patient with systemic lupus erythematosus
Gabriele Noble-Jamieson1, David Jayne, Elizabeth Hook
1Departments of Paediatric Gastroenterology, Hepatology & Nutrition, Adult Renal Medicine and Histopathology at Addenbrookes NHS Trust, Cambridge University Hospitals, UK. gabriele.noble-jamieson@addenbrookes.nhs.uk
Unlabelled:
Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease characterized by the presence of auto-antibodies. Liver enzyme abnormalities are common but clinical liver dysfunction with jaundice is rare. We report a juvenile female patient with SLE who developed jaundice 9 months after her initial presentation. Further investigations including liver biopsy and magnetic resonance cholangio-pancreatography revealed two likely pathologies for her liver dysfunction; amoxicillin-clavulanic acid induced cholestasis and auto-immune cholangiopathy. The hyperbilirubinaemia resolved spontaneously 3 months after exposure to amoxicillin-clavulanic acid; however, the elevation in Alanine transaminase and Gamma-glutamyl transpeptidase persisted until intensive immunosuppressive therapy achieved complete remission.
Conclusion:
We report a rare case of a juvenile patient with SLE and auto-immune cholangiopathy. The use of cholangio-pancreatography as part of the diagnostic work-up achieved the final diagnosis.
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