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Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
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Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.

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Related Experiment Video

Updated: May 25, 2026

Microfabricated Platforms for Mechanically Dynamic Cell Culture
15:21

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Pressure-actuated cellular structures.

M Pagitz1, E Lamacchia, J M A M Hol

  • 1Aerospace Structures and Computational Mechanics Group, Delft University of Technology, The Netherlands. m.e.pagitz@tudelft.nl

Bioinspiration & Biomimetics
|January 27, 2012
PubMed
Summary

Engineers can now design reliable, energy-efficient morphing structures inspired by plant movements. These structures use connected prismatic cells to achieve large strength-to-weight ratios for various applications.

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Area of Science:

  • Engineering
  • Materials Science
  • Biomimetics

Background:

  • Rigid structures have limited optimal operating conditions.
  • Morphing structures offer adaptability for future engineering designs.
  • A high strength-to-weight ratio is crucial for widespread applicability.

Purpose of the Study:

  • To propose a novel concept for reliable and energy-efficient morphing structures.
  • To mimic the nastic movement of plants for structural design.
  • To develop structures with a large strength-to-weight ratio.

Main Methods:

  • Connecting prismatic cells with tailored pentagonal and/or hexagonal cross-sections.
  • Utilizing cell pressure to induce shape changes into target configurations.
  • Developing an efficient algorithm for calculating equilibrium shapes and cross-sectional geometries.

Main Results:

  • Demonstrated a novel bio-inspired approach to morphing structures.
  • Successfully computed equilibrium shapes and optimized cross-sectional geometries.
  • Validated the concept through diverse examples, including propulsion devices and aircraft wings.

Conclusions:

  • The proposed concept enables the creation of adaptable and efficient morphing structures.
  • Plant-inspired design offers a promising avenue for advanced engineering solutions.
  • The developed algorithm and methodology are effective for designing complex morphing systems.