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KAREBrowser: SNP database of Korea Association REsource Project
Chang Bum Hong1, Young Jin Kim, Sanghoon Moon
1Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Korea.
BMB Reports
|January 28, 2012
Summary
The Korea Association Resource (KARE) project created a browser for large-scale genome-wide association study (GWAS) data. This resource offers 1.5 million single nucleotide polymorphisms (SNPs) from 8,842 Korean individuals.
Area of Science:
- Genomics
- Bioinformatics
- Population Genetics
Background:
- Existing human genome databases like HapMap and HGDP have limitations due to small sample sizes.
- Large-scale genetic studies are crucial for understanding human genetic diversity and disease associations.
Purpose of the Study:
- To develop a publicly accessible web-based system for visualizing and navigating genome data from the Korea Association Resource (KARE) project.
- To provide comprehensive single nucleotide polymorphism (SNP) information derived from a large Korean population cohort.
Main Methods:
- Conducted a Genome-Wide Association Study (GWAS) involving 8,842 Korean subjects.
- Developed the KARE browser, a web-based application utilizing the generic genome browser (GBrowse) platform.
- Integrated 1.5 million SNPs and associated genomic features and annotations into the KARE browser.
Main Results:
- The KARE browser offers interactive visualization of genomic data.
- Provides access to a substantial dataset of 1.5 million SNPs from 8,842 Korean individuals.
- Enables users to explore population-based genetic information effectively.
Conclusions:
- The KARE browser enhances public access to large-scale Korean genomic data.
- Facilitates research in human genetics and population-specific disease associations.
- The developed system serves as a valuable resource for the scientific community.
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