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Updated: May 25, 2026
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
New developments in the prevention of intravascular catheter associated infections
Angela L Hewlett1, Mark E Rupp
1Division of Infectious Diseases, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA. alhewlett@unmc.edu
Insights
Preventing central line-associated bloodstream infections (CLA-BSI) is crucial for patient safety and reducing healthcare costs. Implementing universal preventative measures and considering technological innovations can significantly decrease CLA-BSI rates.
Area of Science:
- Healthcare-associated infections
- Infection control
- Patient safety
Background:
- Central line-associated bloodstream infections (CLA-BSI) are a major cause of patient harm and increased healthcare expenses.
- A significant proportion of CLA-BSI cases are preventable, highlighting the need for effective intervention strategies.
Purpose of the Study:
- To outline the key recommendations from the recent CDC Guideline for the elimination of preventable CLA-BSI.
- To emphasize the importance of universal preventative measures and the role of technological innovations.
Main Methods:
- Implementation of collaborative performance improvement initiatives.
- Utilization of checklists and bundles for central line insertion and maintenance.
- Adherence to maximal sterile barrier precautions and chlorhexidine skin preparation.
Main Results:
- Universal preventative measures are effective in reducing CLA-BSI rates.
- Technological innovations serve as adjunctive strategies when universal measures are insufficient.
Conclusions:
- Eliminating preventable CLA-BSI is achievable through consistent application of evidence-based practices.
- A multi-faceted approach combining universal precautions and advanced technologies is recommended for optimal CLA-BSI prevention.
Abstract:
Central line-associated bloodstream infections (CLA-BSI) are one of the leading causes of healthcare-associated infections, resulting in significant morbidity and substantial excess cost. There is a growing recognition that most CLA-BSIs are preventable. Elimination of preventable CLA-BSI is the focus of a recently released CDC Guideline. Universal preventative measures include collaborative performance improvement using checklists and bundles, education of persons who insert and maintain catheters, maximal sterile barrier precautions, and chlorhexidine skin preparation. Technologic innovations including coated catheters, antimicrobial impregnated dressings, and antimicrobial lock solutions should be considered if the rate of CLA-BSI is not acceptable after application of universal precautions.
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