Related Experiment Video
Updated: May 25, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Clinical and research diagnostic criteria for Alzheimer's disease
Marie Sarazin1, Leonardo Cruz de Souza, Stéphane Lehéricy
1Université Pierre et Marie Curie Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, UMR-S975, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. marie.sarazin@psl.aphp.fr
Abstract:
In contrast with the previous criteria published in 1984 by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association, the new criteria proposed in 2007 incorporated in the diagnostic framework the use of biomarkers that are able to assess the underlying pathophysiologic mechanism. The combination of clinical and biologic approaches makes a diagnosis of Alzheimer's disease possible before the dementia stage. The core clinical criteria continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the specificity for the diagnosis of Alzheimer's disease.
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction
Alzheimer's Disease: Treatment
Dementia
The progression of dementia is generally gradual.
