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Related Concept Videos

Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

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Related Experiment Video

Updated: May 25, 2026

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

Age-related changes in the auditory brainstem response.

Dawn Konrad-Martin1, Marilyn F Dille, Garnett McMillan

  • 1VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR 97239, USA. dawn.martin@va.gov

Journal of the American Academy of Audiology
|January 31, 2012
PubMed
Summary
This summary is machine-generated.

Aging significantly reduces auditory brainstem response (ABR) peak amplitudes and increases latencies, particularly in early waves. These changes, observed in veterans, suggest reduced auditory nerve units and central ABR generators due to aging.

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Area of Science:

  • Neuroscience
  • Audiology
  • Gerontology

Background:

  • The auditory brainstem response (ABR) is a measure of the auditory pathway's electrical activity.
  • Aging is known to affect sensory systems, including hearing and neural processing.

Purpose of the Study:

  • To identify and quantify the effects of aging on auditory brainstem response (ABR) measures.
  • To determine how click rate and hearing impairment modify the effects of aging on ABR.

Main Methods:

  • 131 participants (26-71 years old) underwent ABR testing at various click rates.
  • Analysis focused on wave amplitudes, latencies, and interpeak latencies (IPIs).
  • Participants had mild hearing impairment; subgroups were analyzed based on hearing thresholds.

Main Results:

  • Aging substantially decreased ABR peak amplitudes, especially for waves I and III at lower click rates.
  • Aging increased ABR peak latencies, with significant shifts in early waves (I and III).
  • The I-V interpeak latency interval (IPI) remained unchanged with age, suggesting central auditory pathway integrity.

Conclusions:

  • Aging significantly impacts ABR by reducing peak amplitudes and altering latencies, indicating reduced auditory nerve unit function.
  • The findings suggest aging affects the number and/or synchrony of auditory nerve fibers and central auditory processing units.
  • Hearing impairment further diminishes ABR amplitudes and prolongs latencies, independent of aging effects within this cohort.